Pharmacokinetics ADME
Pharmacology · page 110
- ADME = absorption, distribution, metabolism, excretion
- Only free/unbound drug (not albumin-bound) is active; displacement creates interaction risk
- Metabolism mostly in liver (cytochrome P450); prodrugs inactive until metabolized
- Excretion mostly via kidney; kidney or liver disease causes accumulation, so dose adjust
- Cats are deficient in glucuronidation: acetaminophen toxic, aspirin cleared slowly
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